Quinoprazine

Quinoprazine is a potent inhibitor of Vaccinia virus DNA synthesis with an IC50 value of 10 μM. Quinoprazine has antimalarial activity against Plasmodium berghei and also displays antiprion potency, significantly decreases PrPSc levels[1]-[5].

Product Specifications

CAS Number

[115618-99-0]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/quinoprazine.html

Solubility

10 mM in DMSO

Smiles

CCN(CC1)CCN1C(C=C2)=CC=C2NC3=C4C=C5C=CC=CC5=CC4=NC=C3

Molecular Formula

C25H26N4

Molecular Weight

382.50

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Mikhaĭlitsyn FS, et al. The search for new antiparasitic agents. 10. The synthesis, toxicological and antimalarial properties of nitrogen-containing heterocycles with a 4- (4-alkylpiperazinyl-1) phenylamine substituent (the preparation quinoprazine) . Med Parazitol (Mosk) . 1992 Jan-Feb; (1) :50-3. Russian. |[2]Ricciardi RP, et al. Therapeutic compounds for blocking DNA synthesis of POX viruses: United States, US20100035887[P]. 2010-02-11.|[3]Renslo AR, et al. Preparation of antiprion compounds containing thiazole-amine for treating neurodegenerative diseases: World Intellectual Property Organization, WO2013033037[P]. 2013-03-07. |[4]Silber BM, et al. Antiprion compounds that reduce PrP (Sc) levels in dividing and stationary-phase cells. Bioorg Med Chem. 2013 Dec 15;21 (24) :7999-8012. |[5]Mikhaĭlitsyn FS, et al. The search for new antiparasitic agents. 8. The synthesis and study of the acute toxicity, anti-alveolar hydatid and antihymenolepiasis activity of 1-alkyl-4[4- (heterylamino) phenyl]piperazines]. Med Parazitol (Mosk) . 1991 Sep-Oct; (5) :55-7. Russian.