AM-1488

AM-1488 is a potent, orally active glycine receptor (GlyR) potentiator (hGlyRα3 EC50=0.45 μM) [1][2].

Product Specifications

CAS Number

[2079895-60-4]

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/am-1488.html

Solubility

10 mM in DMSO

Smiles

O=C1[C@@]2([H])[C@@](CN(C2)S(=O)(C3=CC=C(OC=C4)C4=C3)=O)([H])C5=CN=CC=C5N1C

Molecular Formula

C19H17N3O4S

Molecular Weight

383.42

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501

References & Citations

[1]Xin Huang, et al. Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators. Nat Struct Mol Biol. 2017 Feb;24 (2) :108-113.|[2]Howard Bregman, et al. The Discovery and Hit-to-Lead Optimization of Tricyclic Sulfonamides as Potent and Efficacious Potentiators of Glycine Receptors. J Med Chem. 2017 Feb 9;60 (3) :1105-1125.