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TRPC3/6-IN-1

TRPC3/6-IN-1 is a potent selectivity blocker of the canonical transient receptor channels (TRPC3/6), has block potency for hTRPC3 and hTRPC6 with IC50 values of 1260 nM and 500 nM, respectively. TRPC3/6-IN-1 can be used for the research of chronic models of heart failure[1].

Product Specifications

CAS Number

736945-96-3

UNSPSC

12352005

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/trpc3-6-in-1.html

Solubility

10 mM in DMSO

Smiles

COC1=CC=C(NC2=NC(C(N3CCC4=C(C3)C=CC=C4)=O)=CS2)C=C1

Molecular Formula

C20H19N3O2S

Molecular Weight

365.45

References & Citations

[1]David G Washburn, et al. The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino-thiazole pharmacophore. Bioorg Med Chem Lett. 2013 Sep 1;23 (17) :4979-84.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

TRPC3

Available Sizes

Frequently Asked Questions

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