SJ1008030 (TFA)
SJ1008030 (compound 8) TFA is a JAK2 PROTAC which selectively degrades JAK2. SJ1008030 TFA inhibits MHH–CALL-4 cell growth with an IC50 of 5.4 nM. SJ1008030 TFA can be used for the research of leukemia[1].
Product Specifications
CAS Number
2863634-97-1
UNSPSC
12352005
Target
JAK; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; PROTAC; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sj1008030-tfa.html
Purity
99.81
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=S(CC)(N1CC(N2C=C(C=N2)C3=C4C=CNC4=NC(NC5=CC=C(C=C5)C(NCCN6CCN(CC6)C7=CC=C8C(N(C9CCC(NC9=O)=O)C(C8=C7)=O)=O)=O)=N3)(CC#N)C1)=O.OC(C(F)(F)F)=O
Molecular Formula
C44H44F3N13O9S
Molecular Weight
987.96
References & Citations
[1]Chang Y, et al. Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia. Blood. 2021 Dec 9;138 (23) :2313-2326.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK2
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Human Grainyhead like protein 1 homolog (GRHL1) activation kit by CRISPRa
![GC1q R Mouse Monoclonal Antibody [A8F5]](https://cdn.genprice.uk/products/992/68dd1c8e061270361ea82623/imageurl/ha601068.webp)