Epothilone E

Epothilone E is a related compound of epothilone, which inhibits microtubule protein function and blocks cell division, and has anti-tumor activity[1].

Product Specifications

CAS Number

[201049-37-8]

UNSPSC

12352005

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/epothilone-e.html

Solubility

10 mM in DMSO

Smiles

OCC1=NC(/C=C([C@@H]2C[C@@]3([H])[C@](CCC[C@@H]([C@@H]([C@H](C(C(C)([C@H](CC(O2)=O)O)C)=O)C)O)C)([H])O3)\C)=CS1

Molecular Formula

C26H39NO7S

Molecular Weight

509.66

References & Citations

[1]K. C. Nicolaou, et al. Total synthesis of epothilone E and analogues with modified side chains through the Stille coupling reaction[J]. Angewandte Chemie International Edition, 1998, 37 (1‐2) : 84-87.