ZLc-002
ZLc-002 is a selective inhibitor of nNOS-Capon coupling. ZLc-002 suppresses inflammatory nociception and chemotherapy-induced neuropathic pain. ZLc-002 can be used for the research of anxiety disorder and inflammation[1][2][3].
Product Specifications
CAS Number
1446971-41-0
UNSPSC
12352211
Target
NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/zlc-002.html
Solubility
10 mM in DMSO
Smiles
COC(CC(N[C@H](C(C)C)C(OC)=O)=O)=O
Molecular Formula
C10H17NO5
Molecular Weight
231.25
References & Citations
[1]Ni HY, et al.Dissociating nNOS (Neuronal NO Synthase) -CAPON (Carboxy-Terminal Postsynaptic Density-95/Discs Large/Zona Occludens-1 Ligand of nNOS) Interaction Promotes Functional Recovery After Stroke via Enhanced Structural Neuroplasticity. Stroke. 2019 Mar;50 (3) :728-737. |[2]Zhu LJ, et al. nNOS-CAPON blockers produce anxiolytic effects by promoting synaptogenesis in chronic stress-induced animal models of anxiety. Br J Pharmacol. 2020 Aug;177 (16) :3674-3690.|[3]Zhu LJ, et al.CAPON-nNOS coupling can serve as a target for developing new anxiolytics. Nat Med. 2014 Sep;20 (9) :1050-4. doi: 10.1038/nm.3644. Epub 2014 Aug 17.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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