Sacibertinib
Sacibertinib is a tyrosine kinase (Trk) inhibitor with EC50 value of 110 nM and 244 nM for EGFR-TK phosphorylation and HER2, respectively. Antineoplastic activity[1].
Product Specifications
CAS Number
1351941-69-9
UNSPSC
12352005
Target
EGFR; Trk Receptor
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sacibertinib.html
Solubility
10 mM in DMSO
Smiles
CN(C)C/C=C/C(NC1=CC(C(NC2=CC(Cl)=C(C=C2)OCC3=CC=CC=N3)=C(C#N)C=N4)=C4C=C1O[C@H]5CCOC5)=O
Molecular Formula
C32H31ClN6O4
Molecular Weight
599.08
References & Citations
[1]International Nonproprietary Names for Pharmaceutical Substances (INN) . WHO Drug Information, Vol. 36, No. 2, 2022.|[2]Hesheng Zhang, et al. Cyanoquinoline derivatives. CA2802130A1 (Example 138)
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1; ErbB2/HER2
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