Manusiran (sodium)

Manusiran (SLN124) sodium, a GalNAc conjugated 19-mer siRNA targeting TMPRSS6 (transmembrane protease serine 6), reduces plasma iron and increases hepcidin levels[1][2].

Product Specifications

Product Name Alternative

Divesiran sodium

UNSPSC

12352208

Target

Ser/Thr Protease; Small Interfering RNA (siRNA) ; TMPRSS6

Type

Oligonucleotides

Related Pathways

Epigenetics; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/manusiran-sodium.html

Solubility

10 mM in H2O

Smiles

[Manusiran(sodium)]

Molecular Formula

C434H532F19N145Na38O270P40S10

Molecular Weight

14058.53 (free acid)

References & Citations

[1]Vadolas J, Ng GZ, Kysenius K, et al. SLN124, a GalNac-siRNA targeting transmembrane serine protease 6, in combination with deferiprone therapy reduces ineffective erythropoiesis and hepatic iron-overload in a mouse model of β-thalassaemia. Br J Haematol. 2021;194 (1) :200-210.|[2]Altamura S, Schaeper U, Dames S, et al. SLN124, a GalNAc-siRNA Conjugate Targeting TMPRSS6, Efficiently Prevents Iron Overload in Hereditary Haemochromatosis Type 1. Hemasphere. 2019;3 (6) :e301.