Manusiran
Product Specifications
UNSPSC Description
Manusiran (SLN124), a GalNAc conjugated 19-mer siRNA targeting TMPRSS6 (transmembrane protease serine 6), reduces plasma iron and increases hepcidin levels of healthy volunteers[1][2].
Target Antigen
Ser/Thr Protease; Small Interfering RNA (siRNA)
Type
Oligonucleotides
Related Pathways
Epigenetics;Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/manusiran.html
Solubility
10 mM in DMSO
Smiles
[Manusiran]
Molecular Weight
14058.53
References & Citations
[1]WHO Drug Information. International Nonproprietary Names for Pharmaceutical|[2]Vadolas J, Ng GZ, Kysenius K, et al. SLN124, a GalNac-siRNA targeting transmembrane serine protease 6, in combination with deferiprone therapy reduces ineffective erythropoiesis and hepatic iron-overload in a mouse model of β-thalassaemia. Br J Haematol. 2021;194(1):200-210.|[3]Altamura S, Schaeper U, Dames S, et al. SLN124, a GalNAc-siRNA Conjugate Targeting TMPRSS6, Efficiently Prevents Iron Overload in Hereditary Haemochromatosis Type 1. Hemasphere. 2019;3(6):e301.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147278/Manusiran-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147278/
Clinical Information
No Development Reported
CAS Number
2646704-10-9
Curated Selection
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