Manusiran
Manusiran (SLN124), a GalNAc conjugated 19-mer siRNA targeting TMPRSS6 (transmembrane protease serine 6), reduces plasma iron and increases hepcidin levels of healthy volunteers[1][2].
Product Specifications
CAS Number
[2646704-10-9]
Product Name Alternative
Divesiran
UNSPSC
12352208
Target
Ser/Thr Protease; Small Interfering RNA (siRNA) ; TMPRSS6
Type
Oligonucleotides
Related Pathways
Epigenetics; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/manusiran.html
Solubility
10 mM in DMSO
Smiles
[Manusiran]
Molecular Formula
C434H570F19N145O270P40S10
Molecular Weight
14058.53
References & Citations
[1]WHO Drug Information. International Nonproprietary Names for Pharmaceutical|[2]Vadolas J, Ng GZ, Kysenius K, et al. SLN124, a GalNac-siRNA targeting transmembrane serine protease 6, in combination with deferiprone therapy reduces ineffective erythropoiesis and hepatic iron-overload in a mouse model of β-thalassaemia. Br J Haematol. 2021;194 (1) :200-210.|[3]Altamura S, Schaeper U, Dames S, et al. SLN124, a GalNAc-siRNA Conjugate Targeting TMPRSS6, Efficiently Prevents Iron Overload in Hereditary Haemochromatosis Type 1. Hemasphere. 2019;3 (6) :e301.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Curated Selection
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SERCA1 (ATP2A1, ATPase, Ca++ transporting, Cardiac Muscle, Fast Twitch 1, ATP2A, OTTHUMP00000162562, SR Ca (2+) -ATPase 1, Calcium pump 1, Calcium-transporting ATPase sarcoplasmic reticulum Type, Fast Twitch skeletal Muscle isoform, Endoplasmic reticulum class 1/2 Ca (2+) ATPase, Sarcoplasmic/endoplasm)
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