What is the catalog number for Manusiran?

The catalog number for Manusiran is HY-147278.

What sizes are available for Manusiran?

Manusiran is available in the following size(s): 1 Each.

Is Manusiran in stock?

Manusiran is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Manusiran?

Manusiran is manufactured by QuantiMol.

What is the estimated delivery time for Manusiran?

Estimated delivery time for Manusiran is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Manusiran?

The safety data sheet for Manusiran is available here: http://file.medchemexpress.com/batch_PDF/HY-147278/.

Manusiran

Manusiran (SLN124), a GalNAc conjugated 19-mer siRNA targeting TMPRSS6 (transmembrane protease serine 6), reduces plasma iron and increases hepcidin levels of healthy volunteers[1][2].

Product Specifications

CAS Number

2646704-10-9

Product Name Alternative

Divesiran

UNSPSC

12352208

Target

Ser/Thr Protease; Small Interfering RNA (siRNA) ; TMPRSS6

Type

Oligonucleotides

Related Pathways

Epigenetics; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/manusiran.html

Solubility

10 mM in DMSO

Smiles

[Manusiran]

Molecular Formula

C434H570F19N145O270P40S10

Molecular Weight

14058.53

References & Citations

[1]WHO Drug Information. International Nonproprietary Names for Pharmaceutical|[2]Vadolas J, Ng GZ, Kysenius K, et al. SLN124, a GalNac-siRNA targeting transmembrane serine protease 6, in combination with deferiprone therapy reduces ineffective erythropoiesis and hepatic iron-overload in a mouse model of β-thalassaemia. Br J Haematol. 2021;194 (1) :200-210.|[3]Altamura S, Schaeper U, Dames S, et al. SLN124, a GalNAc-siRNA Conjugate Targeting TMPRSS6, Efficiently Prevents Iron Overload in Hereditary Haemochromatosis Type 1. Hemasphere. 2019;3 (6) :e301.