RIPK2-IN-2
RIPK2-IN-2 (example 25) is a RIP2 kinase PROTAC inhibitor. RIPK2-IN-2 can block RIP2-dependent proinflammatory signaling, regulated RIP2 kinase activity in auto inflammatory diseases[1].
Product Specifications
CAS Number
2143956-20-9
UNSPSC
12352005
Target
PROTACs; RIP kinase
Type
Reference compound
Related Pathways
Apoptosis; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ripk2-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCC(CC1)[C@H](NC([C@H](C)NC)=O)C(N2[C@@](C3=NC(C(C4=CC=C(C=C4)F)=O)=CS3)([H])CCC2)=O)C5=CN=C(N=C5)N(CC6)CCN6CCOC(C(S(C(C)(C)C)(=O)=O)=C7)=CC8=C7C(NC9=NNC(C)=C9C)=NC=N8
Molecular Formula
C53H65FN14O7S2
Molecular Weight
1093.30
References & Citations
[1]Conjugates comprising ripk2 inhibitors, WO2017182418 (example 25)
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RIPK2
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