Antimalarial agent 13

Antimalarial agent 13 (Compound 1) is a potent antimalarial agent. Antimalarial agent 13 shows inhibition with EC50 values of 124 nM and 2.5 μM against P. falciparum parasite and HepG2, respectively[1].

Product Specifications

CAS Number

[431884-01-4]

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/antimalarial-agent-13.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC=CC(NC2=NC(NCC3=CC=CO3)=C4C=CC=CC4=N2)=C1

Molecular Formula

C19H15ClN4O

Molecular Weight

350.80

References & Citations

[1]Gilson PR, et al. Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity. J Med Chem. 2017 Feb 9;60 (3) :1171-1188.