QH536
QH536 (Compound 29) is a potent HMGCR degrader with an EC50 of 0.22 μM. QH536 has no side-effect of inducing cholesterol accumulation in cells. QH536 shows anti-inflammatory and can be used for cardiovascular disease and nonalcoholic steatohepatitis research[1].
Product Specifications
CAS Number
2754254-07-2
UNSPSC
12352005
Target
HMG-CoA Reductase (HMGCR)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/qh536.html
Solubility
10 mM in DMSO
Smiles
C[C@@](C1=CC2)(CC(C=NN3C(C)=O)=C3C(C)1C)[C@](CC4)([H])[C@]2([H])[C@@](CC[C@]5([H])[C@H](C)CCC(N6CCOCC6)=O)([H])[C@]45C
Molecular Formula
C33H49N3O3
Molecular Weight
535.76
References & Citations
[1]Li XZ, et al. Synthesis of heterocyclic ring-fused analogs of HMG499 as novel degraders of HMG-CoA reductase that lower cholesterol. Eur J Med Chem. 2022 Jun 5;236:114323.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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