α1A-AR Degrader 9c

α1A-AR Degrader 9c (compound 9c) is a potent, selective and reversible α1A-AR (Adrenergic receptor) PROTAC degrader, with a DC50 of 2.86 μM. α1A-AR Degrader 9c induces α1A-AR degradation can be attributed to proteasomal degradation. α1A-AR Degrader 9c inhibits the proliferation of PC-3 cells, with an IC50 of 6.12 μM. α1A-AR Degrader 9c shows antitumor activity, and can be used for prostate cancer research[1].

Product Specifications

CAS Number

[2863635-02-1]

UNSPSC

12352005

Target

Adrenergic Receptor; PROTACs

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/α1a-ar-degrader-9c.html

Purity

99.60

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)COCCOCCOCCN4N=NC(C(N5CCN(C6=NC(N)=C7C=C(OC)C(OC)=CC7=N6)CC5)=O)=C4

Molecular Formula

C38H43N11O11

Molecular Weight

829.82

References & Citations

[1]Li Z, et al. First small-molecule PROTACs for G protein-coupled receptors: inducing α1A-adrenergic receptor degradation. Acta Pharm Sin B. 2020 Sep;10 (9) :1669-1679.