Egaptivon pegol (sodium)
Egaptivon pegol sodium is an aptamer, which blocks binding of the von Willebrand Factor (VWF) to platelet GPIb receptors. Egaptivon pegol sodium has anti-thrombotic efficacy.
Product Specifications
Product Name Alternative
ARC 1779 (sodium)
UNSPSC
12352208
Target
Integrin
Type
Oligonucleotides
Related Pathways
Cytoskeleton
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/egaptivon-pegol-sodium.html
Purity
92.75
Solubility
10 mM in H2O
Smiles
[Egaptivonpegol(sodium)]
Molecular Formula
C413H506N144Na40O275P40S (C2H4O) n
Molecular Weight
54845.90
References & Citations
[1]Avdonin PP, Trufanov SK, Rybakova EY, Tsitrina AA, Goncharov NV, Avdonin PV. The Use of Fluorescently Labeled ARC1779 Aptamer for Assessing the Effect of H2O2 on von Willebrand Factor Exocytosis. Biochemistry (Mosc) . 2021;86 (2) :123-131. |[2]Jilma-Stohlawetz P, Gorczyca ME, Jilma B, Siller-Matula J, Gilbert JC, Knöbl P. Inhibition of von Willebrand factor by ARC1779 in patients with acute thrombotic thrombocytopenic purpura. Thromb Haemost. 2011;105 (3) :545-552. |[3]Spiel AO, Mayr FB, Ladani N, et al. The aptamer ARC1779 is a potent and specific inhibitor of von Willebrand Factor mediated ex vivo platelet function in acute myocardial infarction. Platelets. 2009;20 (5) :334-340.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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