Egaptivon pegol

Egaptivon pegol (ARC1779) is an aptamer, which blocks binding of the von Willebrand Factor (VWF) to platelet GPIb receptors. Egaptivon pegol has anti-thrombotic efficacy.

Product Specifications

CAS Number

[934868-74-3]

Product Name Alternative

ARC 1779

UNSPSC

12352208

Target

Integrin

Type

Oligonucleotides

Related Pathways

Cytoskeleton

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/egaptivon-pegol.html

Purity

92.75

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

[Egaptivonpegol]

Molecular Formula

C413H546N144O275P40S (C2H4O) n

Molecular Weight

53926.29

References & Citations

[1]Avdonin PP, Trufanov SK, Rybakova EY, Tsitrina AA, Goncharov NV, Avdonin PV. The Use of Fluorescently Labeled ARC1779 Aptamer for Assessing the Effect of H2O2 on von Willebrand Factor Exocytosis. Biochemistry (Mosc) . 2021;86 (2) :123-131. |[2]Jilma-Stohlawetz P, Gorczyca ME, Jilma B, Siller-Matula J, Gilbert JC, Knöbl P. Inhibition of von Willebrand factor by ARC1779 in patients with acute thrombotic thrombocytopenic purpura. Thromb Haemost. 2011;105 (3) :545-552. |[3]Spiel AO, Mayr FB, Ladani N, et al. The aptamer ARC1779 is a potent and specific inhibitor of von Willebrand Factor mediated ex vivo platelet function in acute myocardial infarction. Platelets. 2009;20 (5) :334-340.