Cyclic HPMPC
Cyclic HPMPC is a potent antiviral agent. Cyclic HPMPC can increase arterial oxygen saturation levels in lethal vaccinia virus (IHD strain) -infected mice. Cyclic HPMPC improves the outcome of congenital guinea pig cytomegalovirus (GPCMV) infection and decreases viral replication in guinea pig model[1][2].
Product Specifications
CAS Number
127757-45-3
UNSPSC
12352005
Target
CMV; Orthopoxvirus
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/cyclic-hpmpc.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C=CC(N)=N1)C[C@H](OC2)CO[P]2(O)=O
Molecular Formula
C8H12N3O5P
Molecular Weight
261.17
References & Citations
[1]Smee DF, et al. Effects of four antiviral substances on lethal vaccinia virus (IHD strain) respiratory infections in mice. Int J Antimicrob Agents. 2004;23 (5) :430-437.|[2]Bravo FJ, et al. Effect of maternal treatment with cyclic HPMPC in the guinea pig model of congenital cytomegalovirus infection. J Infect Dis. 2006;193 (4) :591-597.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
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