DNA Gyrase-IN-1
DNA Gyrase-IN-1 (compound 42) is a potent and selective DNA gyrase inhibitor with an IC50 value of 2.6 µM. DNA Gyrase-IN-1 has high inhibitory activity against Mycobacterium tuberculosis (Mtb) with MIC of 0.49 µM. DNA Gyrase-IN-1 can be used for researching tuberculosis[1].
Product Specifications
CAS Number
3031486-11-7
UNSPSC
12352005
Target
Bacterial; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dna-gyrase-in-1.html
Solubility
10 mM in DMSO
Smiles
C[C@@H]1N([C@@H](CN2C3=C(C4=C(C=C3CC5([C@]21[H])C(NC(NC5=O)=O)=O)C(OC[C@H]6NC(CC6)=O)=NO4)F)C)C#N
Molecular Formula
C24H24FN7O6
Molecular Weight
525.49
References & Citations
[1]Govender P, et al. Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity. J Med Chem. 2022;65 (9) :6903-6925.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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