HCAIX/XII-IN-1
HCAIX/XII-IN-1 is a potent CAIX/XII inhibitor with the KI values of 0.48 μM and 0.83 μM for CAIX and CAXII, respectively. hCAIX/XII-IN-1 shows antiproliferative activity in vitro. hCAIX/XII-IN-1 induces apoptosis in MCF-7 cells[1].
Product Specifications
CAS Number
[3033040-76-2]
UNSPSC
12352005
Target
Apoptosis; Carbonic Anhydrase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hcaix-xii-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC2=C(OC1=O)C=CC=C2)CN3C(S/C(C3=O)=C\C4=CC=CS4)=O
Molecular Formula
C19H11NO5S2
Molecular Weight
397.42
References & Citations
[1]Eldehna WM, et al. Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms. J Enzyme Inhib Med Chem. 2022; 37 (1) :531-541.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA IX
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6169804-01 0.1 mL
NFAM1 (NFAT Activating Protein with ITAM Motif 1, CNAIP, FLJ40652, bK126B4.4) (APC)
Ask
View Details 
MBS6169804-02 5x 0.1 mL
NFAM1 (NFAT Activating Protein with ITAM Motif 1, CNAIP, FLJ40652, bK126B4.4) (APC)
Ask
View Details 
MBS1004513-01 0.05 mg (E-Coli)
Recombinant Desulfitobacterium hafniense Probable DNA repair protein Dhaf_3719 (Dhaf_3719)
Ask
View Details 
MBS1004513-02 0.2 mg (E-Coli)
Recombinant Desulfitobacterium hafniense Probable DNA repair protein Dhaf_3719 (Dhaf_3719)
Ask
View Details