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HCAIX/XII-IN-1

HCAIX/XII-IN-1 is a potent CAIX/XII inhibitor with the KI values of 0.48 μM and 0.83 μM for CAIX and CAXII, respectively. hCAIX/XII-IN-1 shows antiproliferative activity in vitro. hCAIX/XII-IN-1 induces apoptosis in MCF-7 cells[1].

Product Specifications

CAS Number

3033040-76-2

UNSPSC

12352005

Target

Apoptosis; Carbonic Anhydrase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hcaix-xii-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC2=C(OC1=O)C=CC=C2)CN3C(S/C(C3=O)=C\C4=CC=CS4)=O

Molecular Formula

C19H11NO5S2

Molecular Weight

397.42

References & Citations

[1]Eldehna WM, et al. Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms. J Enzyme Inhib Med Chem. 2022; 37 (1) :531-541.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CA IX

Frequently Asked Questions

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