HA2A/hCA XII modulator 1
HA2A/hCA XII modulator 1 (compound 14), a triazolopirazine, is a potent hA2A adenosine receptor (hA2AAR) antagonist with Kis of 6.4 nM, 4.819 μM, >30 μM for hA2AAR, hA1AR, hA3AR, respectively. hA2A/hCA XII modulator 1 is a potent human carbonic anhydrase XII (hCA XII) inhibitor with Kis of 6.2 nM, 46 nM, 466 nM, 8.351 μM for hCA XII, hCA II, hCA IX and hCA I, respectively. hA2A/hCA XII modulator 1 has the potential for cancer research[1].
Product Specifications
CAS Number
2548963-55-7
UNSPSC
12352005
Target
Adenosine Receptor; Carbonic Anhydrase
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ha2a-hca-xii-modulator-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(C2=CN3C(C(N)=N2)=NN(C4=CC=CC=C4)C3=O)C=C1)C5=CC=C(S(=O)(N)=O)C=C5
Molecular Formula
C24H19N7O4S
Molecular Weight
501.52
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Adenosine A1 receptor (A1R) ; Adenosine A2A receptor (A2AR) ; Adenosine A3 receptor (A3R) ; CA II; CA XII
Frequently Asked Questions
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