LDHA/PDKs-IN-2

LDHA/PDKs-IN-2 (compound 20k) is a potent and dual inhibitor of PDKs and LDHA with IC50s of 1.6 and 0.7 μM, respectively. LDHA/PDKs-IN-2 reduces A549 cell proliferation with an EC50 of 15.7 μM and decreases the lactate formation, and increases oxygen consumption. LDHA/PDKs-IN-2 has the potential for the research of cancer diseases[1].

Product Specifications

CAS Number

[2490699-44-8]

UNSPSC

12352005

Target

PDK-1

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ldha-pdks-in-2.html

Solubility

10 mM in DMSO

Smiles

CC1=C(C(C=CO1)=O)OCCN2CCN(CC2)C(C3=CC=CO3)=O

Molecular Formula

C17H20N2O5

Molecular Weight

332.35

References & Citations

[1]Xiang S, et al. Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation. Eur J Med Chem. 2020;203:112579.