LDHA/PDKs-IN-2
LDHA/PDKs-IN-2 (compound 20k) is a potent and dual inhibitor of PDKs and LDHA with IC50s of 1.6 and 0.7 μM, respectively. LDHA/PDKs-IN-2 reduces A549 cell proliferation with an EC50 of 15.7 μM and decreases the lactate formation, and increases oxygen consumption. LDHA/PDKs-IN-2 has the potential for the research of cancer diseases[1].
Product Specifications
CAS Number
2490699-44-8
UNSPSC
12352005
Target
PDK-1
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ldha-pdks-in-2.html
Solubility
10 mM in DMSO
Smiles
CC1=C(C(C=CO1)=O)OCCN2CCN(CC2)C(C3=CC=CO3)=O
Molecular Formula
C17H20N2O5
Molecular Weight
332.35
References & Citations
[1]Xiang S, et al. Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation. Eur J Med Chem. 2020;203:112579.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
JOT-EK1684Ra-01 96 Well
Rat Atrogin 1;F-box only protein 32,FBXO32 ELISA KIT
Sign In for Pricing
View Details JOT-EK1684Ra-02 48 Well
Rat Atrogin 1;F-box only protein 32,FBXO32 ELISA KIT
Sign In for Pricing
View Details 
bs-15086R-BF750 100 µL
C1r Polyclonal Antibody, AbBy Fluor™ 750 Conjugated
Sign In for Pricing
View Details 