PDE4-IN-9
PDE4-IN-9 (Compound 5j) is a potent inhibitor of PDE4. PDE4-IN-9 exhibits lower IC50 value (1.4 μM) against PDE4 than parent rolipram (2.0 μM) in in vitro enzyme assay. PDE4-IN-9 also displays good in vivo activity in animal models of asthma/COPD and sepsis induced by LPS[1].
Product Specifications
CAS Number
2519450-32-7
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pde4-in-9.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C=C1)C2=NC(C(N3CCS/C3=N\C#N)=O)=CO2
Molecular Formula
C15H12N4O3S
Molecular Weight
328.35
References & Citations
[1]Lin Y, et al. Synthesis and bioactivity of phenyl substituted furan and oxazole carboxylic acid derivatives as potential PDE4 inhibitors. Eur J Med Chem. 2020 Dec 1;207:112795.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE4
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