ATX inhibitor 16

ATX inhibitor 16 is a potent ATX inhibitor with an IC50 of 0.0021 μM. ATX inhibitor 16 shows excellent anti-proliferative activities in breast cancer cells[1].

Product Specifications

CAS Number

[2484811-36-9]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/atx-inhibitor-16.html

Solubility

10 mM in DMSO

Smiles

OC1CCN(CC2=CSC(C3=CC4=C(N(CC)C=C4/C(C(F)(F)F)=N/NC5=NC6=CC=CC=C6S5)C=C3)=N2)CC1

Molecular Formula

C28H27F3N6OS2

Molecular Weight

584.68

References & Citations

[1]Lei H, et al. Structure guided design of potent indole-based ATX inhibitors bearing hydrazone moiety with tumor suppression effects. Eur J Med Chem. 2020 Sep 1;201:112456.