FLT3-IN-15
Product Specifications
UNSPSC Description
FLT3-IN-15 is a highly potent and orally active FLT3 inhibitor with IC50s of 0.87 nM and 0.32 nM for FLT3 and FLT3/D835Y, respectively. FLT3-IN-15 can be used for researching acute myeloid leukemia[1].
Target Antigen
FLT3
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/flt3-in-15.html
Solubility
10 mM in DMSO
Smiles
O=C1NC2=C(/C1=C3NC4=CC=CC=C4C/3=N\OCCN5CCNCC5)C=C(C=C2)F.Cl
Molecular Weight
443.90
References & Citations
[1]Jeong P, Moon Y, Lee JH, et al. Discovery of orally active indirubin-3'-oxime derivatives as potent type 1 FLT3 inhibitors for acute myeloid leukemia. Eur J Med Chem. 2020;195:112205.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-146886/FLT3-IN-15-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-146886/
Clinical Information
No Development Reported
CAS Number
2435562-99-3
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