CAIX/CAXII-IN-1
Compound 9 is the most effective against tumor specific Ca ix/ca XII (ki=29.1 and 8.8 nm), so it is possible to evaluate its cytotoxicity and selectivity to HepG-2, HCT-116 and MCF-7 cancer cell lines in vitro, and its IC50 values to tumor cells are 1.78, 1.94 and 3.07, respectively μ M. It showed that it had obvious cytotoxicity.
Product Specifications
CAS Number
2439165-37-2
UNSPSC
12352005
Target
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/caix-caxii-in-1.html
Solubility
10 mM in DMSO
Smiles
IC1=CC=C(N=C2SCC(NC3=CC=CC=C3CC)=O)C(C(N2C4=CC=C(S(N)(=O)=O)C=C4)=O)=C1
Molecular Formula
C24H21IN4O4S2
Molecular Weight
620.48
References & Citations
[1]Soliman AM, et al. Iodoquinazolinones bearing benzenesulfonamide as human carbonic anhydrase I, II, IX and XII inhibitors: Synthesis, biological evaluation and radiosensitizing activity. Eur J Med Chem. 2020 Aug 15;200:112449.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA II; CA IX; CA XII
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