Tubulin polymerization-IN-12
Tubulin polymerization-IN-12 is a tubulin polymerization inhibitor (IC50=0.75 μM) . Tubulin polymerization-IN-12 arrests cell cycle at G2/M phase, and exhibits cytotoxicity against cancer cells[1].
Product Specifications
CAS Number
2377301-45-4
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tubulin-polymerization-in-12.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(C2=NC3=NC(C)=C(C(N3N2)C4=CC=C(C=C4)[N+]([O-])=O)C(C)=O)=CC(OC)=C1OC
Molecular Formula
C23H23N5O6
Molecular Weight
465.46
References & Citations
[1]Yang F, et al. Synthesis, and biological evaluation of 3, 6-diaryl-[1, 2, 4] triazolo [4, 3-a] pyridine analogues as new potent tubulin polymerization inhibitors[J]. European Journal of Medicinal Chemistry, 2020, 204: 112625.|[2]Yang F, et al. Novel [1, 2, 4] triazolo [1, 5-a] pyrimidine derivatives as potent antitubulin agents: Design, multicomponent synthesis and antiproliferative activities[J]. Bioorganic Chemistry, 2019, 92: 103260.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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