CP19
CP19, a histamine receptor antagonist, is an entry inhibitor against both Ebolavirus (EBOV) and Marburgvirus (MARV) with IC50s of 3.4 μM and 29.5 μM, respectively. CP19 has SI values of 29.4 and 3.4 for EBOV and MARV, respectively. CP19 has antiviral activity[1].
Product Specifications
CAS Number
1018148-68-9
UNSPSC
12352005
Target
Filovirus; Histamine Receptor
Type
Reference compound
Related Pathways
Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/cp19.html
Solubility
10 mM in DMSO
Smiles
O=C1OC2=C(C(C)=C1CC3=CC=CC=C3)C=CC(OCC(CN4CCC(CC4)C(N)=O)O)=C2
Molecular Formula
C26H30N2O5
Molecular Weight
450.53
References & Citations
[1]Yinyi Gao, et al. Development of coumarine derivatives as potent anti-filovirus entry inhibitors targeting viral glycoprotein. Eur J Med Chem. 2020 Oct 15;204:112595.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EBOV; Histamine Receptor; MARV
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