EBOV/MARV-IN-3

EBOV/MARV-IN-3 (compound 32) is a potent EBOV and MARV inhibitor with IC50 values of 0.5, 1.2 µM, respectively. EBOV/MARV-IN-3 binds to the hydrophobic pocket close to EBOV Y517. EBOV/MARV-IN-3 shows antiviral activity[1].

Product Specifications

CAS Number

[2687245-05-0]

UNSPSC

12352005

Target

Filovirus

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ebov-marv-in-3.html

Solubility

10 mM in DMSO

Smiles

CC1=C(C(OC2=CC(OCC(CN3CCC(CC3)C(N)=O)O)=CC=C21)=O)CC4=CC=C(C=C4)OC(F)(F)F

Molecular Formula

C27H29F3N2O6

Molecular Weight

534.52

References & Citations

[1]Gao Y, et al. Development of coumarine derivatives as potent anti-filovirus entry inhibitors targeting viral glycoprotein. Eur J Med Chem. 2020 Oct 15;204:112595.