PRMT4-IN-1

PRMT4-IN-1 is a selective inhibitor of PRMT4 (IC50=3.2 nM) . PRMT4-IN-1 inhibits MCF7 relative viability[1].

Product Specifications

UNSPSC

12352005

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/prmt4-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(OC)C1=CC(O)=C2C=C(NC(NCCCCNC(NC/C=C/[C@H]3O[C@@H](N4C=NC5=C(N)N=CN=C45)[C@H](O)[C@@H]3O)=N)=O)C=CC2=C1

Molecular Formula

C30H36N10O7

Molecular Weight

648.67

References & Citations

[1]Iannelli G, et al. Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach. J Med Chem. 2022 Sep 8;65 (17) :11574-11606.