Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Type II TRK inhibitor 1

Type II TRK inhibitor 1 is a potent TRK inhibitor, which inhibits various TRK fusion protein variants and wild type. Type II TRK inhibitor 1 exhibits antiproliferative activity against Ba/F3 cells harboring CD74-TRKAG667C and ETV6-TRKCG696C fusion proteins with IC50s of 6 nM and 1.7 nM, respectively[1]. Type II TRK inhibitor 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

2937543-72-9

UNSPSC

12352005

Target

Trk Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/type-ii-trk-inhibitor-1.html

Solubility

10 mM in DMSO

Smiles

CN(CCN1)C2=NN3C(C=C2)=NC=C3C#CC4=CC(OCCCCC1=O)=CC(C(NC5=CC(N6C=C(C)N=C6)=CC(C(F)(F)F)=C5)=O)=C4C

Molecular Formula

C35H33F3N8O3

Molecular Weight

670.68

References & Citations

[1]Wang Z, et al. Discovery of the First Highly Selective and Broadly Effective Macrocycle-Based Type II TRK Inhibitors that Overcome Clinically Acquired Resistance. J Med Chem. 2022 Apr 28;65 (8) :6325-6337.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

TrkA; TrkC

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

pLenti-SFFV-Lin28-PGK-GFP
LV555 1 Each

pLenti-SFFV-Lin28-PGK-GFP

Sign In for Pricing
View Details
KCTD16 Polyclonal Antibody, PerCP Conjugated
bs-20315R-PerCP 100 µL

KCTD16 Polyclonal Antibody, PerCP Conjugated

Sign In for Pricing
View Details
ST2 (IL1RL1) Mouse Monoclonal Antibody [Clone 11E3]
E45M19435V-2 50 µL

ST2 (IL1RL1) Mouse Monoclonal Antibody [Clone 11E3]

Sign In for Pricing
View Details
Kif3a sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)
K5026507 1.0 µg DNA

Kif3a sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)

Sign In for Pricing
View Details
TIE2 (TEK) (NM_000459) Human Mutant ORF Clone
RC402255 10 µg

TIE2 (TEK) (NM_000459) Human Mutant ORF Clone

Sign In for Pricing
View Details
ZNF114 Mouse Monoclonal Antibody [Clone:6F4]
E45M18779 100 µg

ZNF114 Mouse Monoclonal Antibody [Clone:6F4]

Sign In for Pricing
View Details