Type II TRK inhibitor 1
Type II TRK inhibitor 1 is a potent TRK inhibitor, which inhibits various TRK fusion protein variants and wild type. Type II TRK inhibitor 1 exhibits antiproliferative activity against Ba/F3 cells harboring CD74-TRKAG667C and ETV6-TRKCG696C fusion proteins with IC50s of 6 nM and 1.7 nM, respectively[1]. Type II TRK inhibitor 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product Specifications
CAS Number
2937543-72-9
UNSPSC
12352005
Target
Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/type-ii-trk-inhibitor-1.html
Solubility
10 mM in DMSO
Smiles
CN(CCN1)C2=NN3C(C=C2)=NC=C3C#CC4=CC(OCCCCC1=O)=CC(C(NC5=CC(N6C=C(C)N=C6)=CC(C(F)(F)F)=C5)=O)=C4C
Molecular Formula
C35H33F3N8O3
Molecular Weight
670.68
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TrkA; TrkC
Frequently Asked Questions
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