PDHK-IN-3

PDHK-IN-3 (compound 7) is a potent PDHK (pyruvate dehydrogenase kinase) inhibitor, with IC50 values of 0.21 and 1.54 μM for PDHK2 and PDHK4, respectively[1].

Product Specifications

UNSPSC

12352005

Target

PDHK

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/pdhk-in-3.html

Solubility

10 mM in DMSO

Smiles

COC(C1=CC2=C(NC3=C(C=CC=C23)C4CC4)N=C1C)=O

Molecular Formula

C17H16N2O2

Molecular Weight

280.32

References & Citations

[1]Bessho Y, et al. Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors. Bioorg Med Chem. 2021 Dec 15;52:116514.