PDHK-IN-3
PDHK-IN-3 (compound 7) is a potent PDHK (pyruvate dehydrogenase kinase) inhibitor, with IC50 values of 0.21 and 1.54 μM for PDHK2 and PDHK4, respectively[1].
Product Specifications
UNSPSC
12352005
Target
PDHK
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pdhk-in-3.html
Solubility
10 mM in DMSO
Smiles
COC(C1=CC2=C(NC3=C(C=CC=C23)C4CC4)N=C1C)=O
Molecular Formula
C17H16N2O2
Molecular Weight
280.32
References & Citations
[1]Bessho Y, et al. Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors. Bioorg Med Chem. 2021 Dec 15;52:116514.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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