PLK1-IN-4
PLK1-IN-4 is a potent and selective PLK1 inhibitor with IC50 apoptosis. PLK1-IN-4 can be used for researching hepatocellular carcinoma[1].
Product Specifications
CAS Number
2622273-55-4
UNSPSC
12352005
Target
Polo-like Kinase (PLK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/plk1-in-4.html
Solubility
10 mM in DMSO
Smiles
COC1=C(C=C2C(CCN2C(CN(C)C)=O)=C1)NC3=NC=C(C(NC4=C(SC=C4)C(OC)=O)=N3)C(F)(F)F
Molecular Formula
C24H25F3N6O4S
Molecular Weight
550.55
References & Citations
[1]Deng Z, et al. Discovery of methyl 3- ((2- ((1- (dimethylglycyl) -5-methoxyindolin-6-yl) amino) -5- (trifluoro-methyl) pyrimidin-4-yl) amino) thiophene-2-carboxylate as a potent and selective polo-like kinase 1 (PLK1) inhibitor for combating hepatocellular carcinoma. Eur J Med Chem. 2020;206:112697.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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