PI3Kδ/γ-IN-2

PI3Kδ/γ-IN-2 is a potent PI3Kδ and PI3Kγ dual inhibitor with IC50s of 1 nM and 4.3 nM, respectively. PI3Kδ/γ-IN-2 has favorable oral bioavailability. PI3Kδ/γ-IN-2 has potential for battling B-cell malignancies[1].

Product Specifications

CAS Number

[2412195-89-0]

UNSPSC

12352005

Target

PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pi3kδ-γ-in-2.html

Solubility

10 mM in DMSO

Smiles

N#CC1=C(N=C(N=C1N2CC3(C[C@H]2C4=NC5=CC=CC(Cl)=C5C(N4C6=CC=CC=C6)=O)CC3)N)N

Molecular Formula

C25H21ClN8O

Molecular Weight

484.94

References & Citations

[1]Tao Q, et al. Structurally novel PI3Kδ/γ dual inhibitors characterized by a seven-membered spirocyclic spacer: The SARs investigation and PK evaluation. Eur J Med Chem. 2020;191:112143.