MAO-B-IN-7

MAO-B-IN-7 is a potent and blood-brain barrier permeable MAO-B and AChE inhibitor with IC50s of 41 nM, 87 nM and 0.3 μM for human AChE, electric eel AChE and MAO-B, respectively. MAO-B-IN-7 can effectively alleviate oxidative stress and neuroinflammatory damage[1].

Product Specifications

CAS Number

[2851012-65-0]

UNSPSC

12352005

Target

Cholinesterase (ChE) ; Monoamine Oxidase; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mao-b-in-7.html

Solubility

10 mM in DMSO

Smiles

CCCCC1OC(C2=CC(OCC3=CC(O)=C(C=C3)CN4CCCCC4)=CC=C21)=O

Molecular Formula

C25H31NO4

Molecular Weight

409.52

References & Citations

[1]Liu Z, et al. Discovery of novel 3-butyl-6-benzyloxyphthalide Mannich base derivatives as multifunctional agents against Alzheimer's disease. Bioorg Med Chem.