TIY-7
TIY-7 is a selective and orally active tropomyosin receptor kinase (TRK) inhibitor. TIY-7 shows enzyme inhibitory activity with IC50s of 2.9, 1.1, 0.7, 0.8, 0.8, 0.2 nM for TRKA, TRKAG595R, TRKAG667C, TRKAF589L, TRKCG623R, TRKCG696A, respectively. TIY-7 shows anti-tumor potency in mouse xenograft model[1].
Product Specifications
CAS Number
2846435-83-2
UNSPSC
12352005
Target
Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tiy-7.html
Solubility
10 mM in DMSO
Smiles
FC1=CC=C(C([C@H]2CCCN2C3=NC4=C(C=NN4C=C3)C5=CNN=C5)=C1)OCC(F)(F)F
Molecular Formula
C21H18F4N6O
Molecular Weight
446.40
References & Citations
[1]Mei LC, et al. Conformational adjustment overcomes multiple drug-resistance mutants of tropomyosin receptor kinase. Eur J Med Chem. 2022 Apr 25;237:114406.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TrkA; TrkC
Frequently Asked Questions
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