SDR-04

SDR-04 is a BET inhibitor and exhibits strong BRD4-BD1 affinity and inhibition activity. SDR-04 potently suppresses MV4;11 cancer cell line proliferation[1].

Product Specifications

CAS Number

[879593-54-1]

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sdr-04.html

Solubility

10 mM in DMSO

Smiles

COC1=CC(C2=C(N3C=CN=CC3=N2)NC4=CC=CC=C4)=CC=C1O

Molecular Formula

C19H16N4O2

Molecular Weight

332.36

References & Citations

[1]Ru Dong, et al. Design, synthesis and anticancer evaluation of 3-methyl-1H-indazole derivatives as novel selective bromodomain-containing protein 4 inhibitors. Bioorg Med Chem. 2021 Dec 29;55:116592.