PD-1/PD-L1-IN-27

PD-1/PD-L1-IN-27 is a potent PD-1/PD-L1 inhibitor with an IC50 value of 134 nM. PD-1/PD-L1-IN-27 shows antitumor effects with low T cell cytotoxicity. PD-1/PD-L1-IN-27 has the ability to activate CD8+ T cells and reduces T cell exhaustion[1].

Product Specifications

CAS Number

[2891831-47-1]

UNSPSC

12352005

Target

PD-1/PD-L1

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pd-1-pd-l1-in-27.html

Solubility

10 mM in DMSO

Smiles

CC1=C(C=CC=C1C2=CC=CC=C2)COC3=CC=C(C(OC4=CC(OC5=C4C=CC6=C5C=CC=C6)=O)=C3)CN7CC8=C(C[C@@H]7C(O)=O)C=CC=C8

Molecular Formula

C44H35NO6

Molecular Weight

673.75

References & Citations

[1]Zhang M, et al. Molecular hybridization used to design and synthesize neo-tanshinlactone derivatives as PD-1/PD-L1 inhibitors. Bioorg Med Chem. 2022; 54:116579.