PD-1/PD-L1-IN-27
Product Specifications
UNSPSC Description
PD-1/PD-L1-IN-27 is a potent PD-1/PD-L1 inhibitor with an IC50 value of 134 nM. PD-1/PD-L1-IN-27 shows antitumor effects with low T cell cytotoxicity. PD-1/PD-L1-IN-27 has the ability to activate CD8+ T cells and reduces T cell exhaustion[1].
Target Antigen
PD-1/PD-L1
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pd-1-pd-l1-in-27.html
Solubility
10 mM in DMSO
Smiles
CC1=C(C=CC=C1C2=CC=CC=C2)COC3=CC=C(C(OC4=CC(OC5=C4C=CC6=C5C=CC=C6)=O)=C3)CN7CC8=C(C[C@@H]7C(O)=O)C=CC=C8
Molecular Weight
673.75
References & Citations
[1]Zhang M, et al. Molecular hybridization used to design and synthesize neo-tanshinlactone derivatives as PD-1/PD-L1 inhibitors. Bioorg Med Chem. 2022; 54:116579.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-146740/PD-1-PD-L1-IN-27-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-146740/
Clinical Information
No Development Reported
CAS Number
2891831-47-1
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