MNK1/2-IN-6
MNK1/2-IN-6 is a potent and selective MNK1/2 inhibitor with IC50s of 2.3 nM and 3.4 nM for MNK1 and MNK2, respectively. MNK1/2-IN-6 induces apoptosis in a concentration-dependent manner[1].
Product Specifications
CAS Number
2771087-94-4
UNSPSC
12352005
Target
Apoptosis; MNK
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mnk1-2-in-6.html
Solubility
10 mM in DMSO
Smiles
N[C@H]1CCCN(C1)C(C2=CC=C(C=C2)C3=NN4C(C5=CC=C6C=NC=CC6=C5)=CN=C4C=C3)=O
Molecular Formula
C27H24N6O
Molecular Weight
448.52
References & Citations
[1]Bu H, et al. Design, synthesis and biological evaluation of imidazopyridazine derivatives containing isoquinoline group as potent MNK1/2 inhibitors. Bioorg Med Chem. 2021; 40:116186.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MNK1; MNK2
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