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MNK1/2-IN-6

MNK1/2-IN-6 is a potent and selective MNK1/2 inhibitor with IC50s of 2.3 nM and 3.4 nM for MNK1 and MNK2, respectively. MNK1/2-IN-6 induces apoptosis in a concentration-dependent manner[1].

Product Specifications

CAS Number

2771087-94-4

UNSPSC

12352005

Target

Apoptosis; MNK

Type

Reference compound

Related Pathways

Apoptosis; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mnk1-2-in-6.html

Solubility

10 mM in DMSO

Smiles

N[C@H]1CCCN(C1)C(C2=CC=C(C=C2)C3=NN4C(C5=CC=C6C=NC=CC6=C5)=CN=C4C=C3)=O

Molecular Formula

C27H24N6O

Molecular Weight

448.52

References & Citations

[1]Bu H, et al. Design, synthesis and biological evaluation of imidazopyridazine derivatives containing isoquinoline group as potent MNK1/2 inhibitors. Bioorg Med Chem. 2021; 40:116186.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MNK1; MNK2

Frequently Asked Questions

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