STAT3-IN-10
STAT3-IN-10 is a STAT3 inhibitor with an IC50 value of 5.18 μM. STAT3-IN-10 directly binds to STAT3 SH2 domain, induces cancer cells apoptosis[1].
Product Specifications
CAS Number
2499491-04-0
UNSPSC
12352005
Target
Apoptosis; STAT
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/stat3-in-10.html
Solubility
10 mM in DMSO
Smiles
COC(C=C1)=CC=C1NC2=CC(C3=C(C2=O)OC(C(C)=O)=C3)=O
Molecular Formula
C17H13NO5
Molecular Weight
311.29
References & Citations
[1]Kai-Rui Feng, et al. Design, synthesis and biological evaluation of novel potent STAT3 inhibitors based on BBI608 for cancer therapy. Eur J Med Chem. 2020 Sep 1;201:112428.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3
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