Dot1L-IN-7
Dot1L-IN-7 (compound 25) is a potent and selective disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 of 1.0 μM. Dot1L-IN-7 selectively killed Mixed Lineage Leukemia (MLL) -AF9 without showing any effect on the growth of E2A-HLF cells[1].
Product Specifications
CAS Number
2580940-76-5
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dot1l-in-7.html
Solubility
10 mM in DMSO
Smiles
CC(C)(C1=CC=C(C=C1)NC(C2=NN(C=N2)CC(NCCN3C=CC4=C3N=CN=C4N)=O)=O)C
Molecular Formula
C23H27N9O2
Molecular Weight
461.52
References & Citations
[1]Garrett S Gibbons, et al. Identification of DOT1L inhibitors by structure-based virtual screening adapted from a nucleoside-focused library. Eur J Med Chem. 2020 Mar 1;189:112023.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DOT1L
Frequently Asked Questions
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