Dot1L-IN-7

Dot1L-IN-7 (compound 25) is a potent and selective disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 of 1.0 μM. Dot1L-IN-7 selectively killed Mixed Lineage Leukemia (MLL) -AF9 without showing any effect on the growth of E2A-HLF cells[1].

Product Specifications

CAS Number

[2580940-76-5]

UNSPSC

12352005

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dot1l-in-7.html

Solubility

10 mM in DMSO

Smiles

CC(C)(C1=CC=C(C=C1)NC(C2=NN(C=N2)CC(NCCN3C=CC4=C3N=CN=C4N)=O)=O)C

Molecular Formula

C23H27N9O2

Molecular Weight

461.52

References & Citations

[1]Garrett S Gibbons, et al. Identification of DOT1L inhibitors by structure-based virtual screening adapted from a nucleoside-focused library. Eur J Med Chem. 2020 Mar 1;189:112023.