RET-IN-16
RET-IN-16 is a potent and selective RET inhibitor with IC50s of 3.98 nM, 8.42 nM, 15.05 nM, 7.86 nM, 5.43 nM and 8.86 nM for RET (WT), RET (M918T), RET (V804L), RET (V804M), RET-CCDC6 and RET-KIF5B, respectively. RET-IN-16 has anticancer effects[1].
Product Specifications
CAS Number
2259657-48-0
UNSPSC
12352005
Target
RET
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ret-in-16.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=C(C=C1OC2=C3C=NNC3=NC(C4=CN=CC=C4)=N2)C(NC5=CC(C(F)(F)F)=C(C=C5)CN6CCN(CC6)C)=O
Molecular Formula
C31H29F3N8O2
Molecular Weight
602.61
References & Citations
[1]Li X, Su J, Yang Y, et al. Discovery of 4-methyl-N- (4- ((4-methylpiperazin- 1-yl) methyl) -3- (trifluoromethyl) phenyl) -3- ((6- (pyridin-3-yl) -1H-pyrazolo[3,4-d]pyrimidin-4-yl) -oxy) benzamide as a potent inhibitor of RET and its gatekeeper mutant. Eur J Med Chem. 2020;207:112755.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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