RIPK2-IN-1
RIPK2-IN-1 (compound 18f) is a potent RIPK2 inhibitor with an IC50 of 51 nM. RIPK2-IN-1 inhibits ALK2 with an IC50 of 5 nM. RIPK2-IN-1 has an IC50 of 390 nM on RIPK2/NOD2 in cell assay[1].
Product Specifications
CAS Number
2245820-70-4
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK) ; RIP kinase
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ripk2-in-1.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(C2=C(N=CC(C3=CC=C(C=C3)N4CCNCC4)=C2)N)=CC(NS(C)(=O)=O)=C1
Molecular Formula
C23H27N5O3S
Molecular Weight
453.56
References & Citations
[1]Chalada Suebsuwong, et al. Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold. Eur J Med Chem. 2020 Aug 15;200:112417.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RIPK2
Available Sizes
Frequently Asked Questions
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