PAK1-IN-1
PAK1-IN-1 is a potent and selective PAK1 inhibitor with an IC50 of 9.8 nM. PAK1-IN-1 inhibits the migration and invasion of PAK1-related tumour cells in a dose-dependent manner[1].
Product Specifications
CAS Number
[2485732-30-5]
UNSPSC
12352005
Target
PAK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pak1-in-1.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=CN(C1=O)C2=CC=C(C(Cl)=C2)C3=CC=C4C(NN=C4C(NCC5=CC=NC=C5)=O)=C3
Molecular Formula
C26H20ClN5O2
Molecular Weight
469.92
References & Citations
[1]Zhang M, et al. Design and synthesis of 1H-indazole-3-carboxamide derivatives as potent and selective PAK1 inhibitors with anti-tumour migration and invasion activities. Eur J Med Chem. 2020 Oct 1;203:112517.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-146681/PAK1-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-146681/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PAK1; PAK4
Curated Selection
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