PAK1-IN-1

PAK1-IN-1 is a potent and selective PAK1 inhibitor with an IC50 of 9.8 nM. PAK1-IN-1 inhibits the migration and invasion of PAK1-related tumour cells in a dose-dependent manner[1].

Product Specifications

CAS Number

[2485732-30-5]

UNSPSC

12352005

Target

PAK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pak1-in-1.html

Solubility

10 mM in DMSO

Smiles

CC1=CC=CN(C1=O)C2=CC=C(C(Cl)=C2)C3=CC=C4C(NN=C4C(NCC5=CC=NC=C5)=O)=C3

Molecular Formula

C26H20ClN5O2

Molecular Weight

469.92

References & Citations

[1]Zhang M, et al. Design and synthesis of 1H-indazole-3-carboxamide derivatives as potent and selective PAK1 inhibitors with anti-tumour migration and invasion activities. Eur J Med Chem. 2020 Oct 1;203:112517.