HDAC6-IN-5
HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-5 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity[1].
Product Specifications
CAS Number
[2413603-15-1]
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE) ; HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hdac6-in-5.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(C=C1)NC2=C3C=CC=CC3=NC4=CC=C(C=C42)Br)NO
Molecular Formula
C20H14BrN3O2
Molecular Weight
408.25
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; HDAC; HDAC1; HDAC2; HDAC3; HDAC4; HDAC5; HDAC6; HDAC7; HDAC9
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Rad9 (S387) (RAD9A, Cell cycle checkpoint control protein RAD9A, DNA repair exonuclease rad9 homolog A) (MaxLight 550)
Rad9 (S387) (RAD9A, Cell cycle checkpoint control protein RAD9A, DNA repair exonuclease rad9 homolog A) (MaxLight 550)