HDAC6-IN-5

HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-5 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity[1].

Product Specifications

CAS Number

[2413603-15-1]

UNSPSC

12352005

Target

Amyloid-β; Cholinesterase (ChE) ; HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/hdac6-in-5.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=C(C=C1)NC2=C3C=CC=CC3=NC4=CC=C(C=C42)Br)NO

Molecular Formula

C20H14BrN3O2

Molecular Weight

408.25

References & Citations

[1]Tseng HJ, et al. Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer's disease. Eur J Med Chem. 2020 Apr 15;192:112193.