UR-MB108
UR-MB108 (Compound 57) is a potent, selective ABCG2 (BCRP) inhibitor with an IC50 of 79 nM. UR-MB108 is stable in blood plasma[1].
Product Specifications
CAS Number
2412461-98-2
UNSPSC
12352005
Target
BCRP
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ur-mb108.html
Solubility
10 mM in DMSO
Smiles
CCC(C1=CC=C(C=C1NC(C2=NC3=C(C=C2)C=CC=C3)=O)C4=CN(N=N4)C5=CC=C(C=C5)CCN6CCC7=C(C6)C=C(C(OC)=C7)OC)=O
Molecular Formula
C40H38N6O4
Molecular Weight
666.77
References & Citations
[1]Frauke Antoni, et al. Tariquidar-related triazoles as potent, selective and stable inhibitors of ABCG2 (BCRP) . Eur J Med Chem. 2020 Apr 1;191:112133.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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